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Article

NOD2/CARD15 gene mutations in patients with familial Mediterranean fever.

Seminars in arthritis and rheumatism - 1 Aug 2012

Berkun Yackov, Karban Amir, Padeh Shai, Pras Elon, Shinar Yael, Lidar Merav, Livneh Avi, Bujanover Yoram

Abstract excerpt

OBJECTIVE: Familial Mediterranean fever (FMF) and Crohn's disease are autoinflammatory disorders, associated with genes (MEFV and NOD2/CARD15, respectively) encoding for regulatory proteins, important in innate immunity, apoptosis, cytokine processing, and inflammation. Although mutations in the MEFV gene were shown to modify Crohn's disease, the role of NOD2/CARD15 gene mutations in the FMF disease phenotype was...

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Source

Identifiers

PMID: 22244368
DOI: 10.1016/j.semarthrit.2011.12.002

Genes

NOD2
MEFV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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