Article
Autophagy can promote but is not required for epithelial cell extrusion in the amnioserosa of the Drosophila embryo.
Autophagy - 1 Feb 2012
Cormier Olga, Mohseni Nilufar, Voytyuk Iryna, Reed Bruce H
Abstract excerpt
During Drosophila embryogenesis the majority of the extra-embryonic epithelium known as the amnioserosa (AS) undergoes programmed cell death (PCD) following the completion of the morphogenetic process of dorsal closure. Approximately ten percent of AS cells, however, are eliminated during dorsal closure by extrusion from the epithelium. Using biosensors that report autophagy and caspase activity in vivo, we...
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