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Article

Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence and MDR1 effect on anti-epileptic drug (phenytoin) absorption.

Genetic testing and molecular biomarkers - 1 Jun 2012

Ponnala Shivani, Chaudhari Jaydip Ray, Jaleel Momin Abdul, Bhiladvala Dilnawaz, Kaipa Prabhakar Rao, Das Undurti N, Hasan Qurratulain

Abstract excerpt

AIMS: To assess the role of MDR1 and gamma-aminobutyric acid receptor-gamma 2 sub unit (GABRG2) gene polymorphism in seizure susceptibility in generalized seizure (GS) and febrile seizure (FS) patients and to evaluate MDR1 C3435T gene polymorphism's role in absorption of the anti-epileptic drug, phenytoin (PHT) in a cohort of patients. METHODS: One hundred twenty-seven cases of seizure (86 GS and 41 FS) patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22239287
DOI: 10.1089/gtmb.2011.0225

Genes

GABRG2

Variants

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