Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection.

doi:10.1111/j.1365-2249.2011.04497.x

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Article

Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection.

Clinical and experimental immunology - 1 Feb 2012

Cmet S, Fabris C, Fattovich G, Falleti E, Bitetto D, Cussigh A, Fontanini E, Fornasiere E, Pirisi M, Toniutto P

Abstract excerpt

Because epidermal growth factor (EGF) up-regulation is characteristic of the cirrhotic liver, we hypothesised that the EGF rs4444903 A > G functional polymorphism might be associated with a worse disease course in patients with chronic HBV infection. To verify this hypothesis, 170 HBV-positive patients (125 males) with a median age of 52 years were studied. Sixty-two of these patients were followed longitudinally...

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PMID: 22236006
DOI: 10.1111/j.1365-2249.2011.04497.x
PMCID: PMC3278696

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