Article
No association of EGF 5'UTR variant A61G and hepatocellular carcinoma in Chinese patients with chronic hepatitis B virus infection.
Pathology - 1 Jan 2009
Qi Peng, Wang Hao, Chen Yue-Ming, Sun Xiao-Juan, Liu Yan, Gao Chun-Fang
Abstract excerpt
OBJECTIVE: Epidermal growth factor (EGF) has many biological functions, including mitogenesis, tumorigenesis, and proliferation of epidermal tissues. Previous studies have reported that the EGF +61 (A/G) single nucleotide polymorphism in the 5'-untranslated region of the EGF gene is functional, and is associated with development of hepatocellular carcinoma (HCC) in liver cirrhosis and various malignancy. Our aim...
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