Article
Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.
JAMA - 2 Jan 2008
Tanabe Kenneth K, Lemoine Antoinette, Finkelstein Dianne M, Kawasaki Hiroshi, Fujii Tsutomu, Chung Raymond T, Lauwers Gregory Y, Kulu Yakup, Muzikansky Alona, Kuruppu Darshini, Lanuti Michael, Goodwin Jonathan M, Azoulay Daniel, Fuchs Bryan C
Abstract excerpt
CONTEXT: Overexpression of epidermal growth factor (EGF) in the liver induces transformation to hepatocellular carcinoma in animal models. Polymorphisms in the EGF gene modulate EGF levels. OBJECTIVE: To assess the relationship among human EGF gene single-nucleotide polymorphism, EGF expression, and risk of hepatocellular carcinoma. DESIGN, SETTING, AND PARTICIPANTS: Molecular mechanisms linking the 61*G allele...
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