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Article

Variations in Helicobacter pylori cytotoxin-associated genes and their influence in progression to gastric cancer: implications for prevention.

PloS one - 1 Jan 2012

Rizzato Cosmeri, Torres Javier, Plummer Martyn, Muñoz Nubia, Franceschi Silvia, Camorlinga-Ponce Margarita, Fuentes-Pananá Ezequiel M, Canzian Federico, Kato Ikuko

Abstract excerpt

Helicobacter pylori (HP) is a bacterium that colonizes the human stomach and can establish a long-term infection of the gastric mucosa. Persistent Hp infection often induces gastritis and is associated with the development of peptic ulcer disease, atrophic gastritis, and gastric adenocarcinoma. Virulent HP isolates harbor the cag (cytotoxin-associated genes) pathogenicity island (cagPAI), a 40 kb stretch of DNA...

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PMID: 22235308
DOI: 10.1371/journal.pone.0029605
PMCID: PMC3250449

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Source receipt: pubmed, retrieved 7 Sept 2026.

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