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Article

SigH of Porphyromonas gingivalis Regulates Oxidative Stress Resistance and Invasion of Oral Epithelial Cells.

The Bulletin of Tokyo Dental College - 13 Dec 2025

Kikuchi Yuichiro, Kokubu Eitoyo, Yonezawa Hideo, Ishihara Kazuyuki

Abstract excerpt

Porphyromonas gingivalis, a key periodontal pathogen, employs extra-cytoplasmic function (ECF) sigma factors to adapt to the dynamic oral environment and establish chronic infection. Among these, PGN_1740 (SigH) has been implicated in oxidative stress response and iron acquisition, yet its transcriptional regulatory mechanisms remain poorly understood. The aim of this study was to elucidate the functional role of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41242733
DOI: 10.2209/tdcpublication.2025-0013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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SigH of Porphyromonas gingivalis Regulates Oxidative Stress Resistance and Invasion of Oral Epithelial Cells.PMID 41242733Read ↗

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The Alternative Sigma Factor SigL Influences <i>Clostridioides difficile</i> Toxin Production, Sporulation, and Cell Surface PropertiesSemantic proximity Read ↗

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The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in <i>Mycobacterium abscessus</i>Semantic proximity Read ↗

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