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Legionella pneumophila LidA Affects Nucleotide Binding and Activity of the Host GTPase Rab1

7 Jan 2012

Abstract excerpt

Legionella pneumophila, the causative agent of a severe pneumonia known as Legionnaires' disease, intercepts material from host cell membrane transport pathways to create a specialized vacuolar compartment that supports bacterial replication. Delivery of bacterial effector proteins into the host cell requires the Dot/Icm type IV secretion system. Several effectors, including SidM, SidD, and LepB, were shown to...

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PMID: 22228731
DOI: 10.1128/jb.06306-11

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Legionella pneumophila LidA Affects Nucleotide Binding and Activity of the Host GTPase Rab1PMID 22228731Read ↗

Targeting of the Small GTPase Rab6A′ by the Legionella pneumophila Effector LidASemantic proximity Read ↗

Legionella pneumophila SidD is a deAMPylase that modifies Rab1.Semantic proximity Read ↗

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.Semantic proximity Read ↗

De-AMPylation of the Small GTPase Rab1 by the Pathogen <i>Legionella pneumophila</i>Semantic proximity Read ↗

Rab1 guanine nucleotide exchange factor SidM is a major phosphatidylinositol 4-phosphate-binding effector protein of Legionella pneumophila.Semantic proximity Read ↗

Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA.Semantic proximity Read ↗

The Legionella pneumophila effector protein DrrA is a Rab1 guanine nucleotide-exchange factor.Semantic proximity Read ↗

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.Semantic proximity Read ↗

Protein LidA from Legionella is a Rab GTPase supereffectorSemantic proximity Read ↗

Anchors for Effectors: Subversion of Phosphoinositide Lipids by LegionellaSemantic proximity Read ↗

Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidDSemantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

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