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Article

Regulation of A Disintegrin And Metalloprotease-33 Expression by Transforming Growth Factor-β

7 Jan 2012

Abstract excerpt

The asthma susceptibility gene, a disintegrin and metalloprotease-33 (ADAM33), is selectively expressed in mesenchymal cells, and the activity of soluble ADAM33 has been linked to angiogenesis and airway remodeling. Transforming growth factor (TGF)-β is a profibrogenic growth factor, the expression of which is increased in asthma, and recent studies show that it enhances shedding of soluble ADAM33. In this study,...

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PMID: 22227561
DOI: 10.1165/rcmb.2011-0030oc

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