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Article

Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner.

Pflugers Archiv : European journal of physiology - 1 Apr 2012

Komatsu Tomoko, Uchida Kunitoshi, Fujita Fumitaka, Zhou Yiming, Tominaga Makoto

Abstract excerpt

Transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable non-selective cation channel that is mainly expressed in primary nociceptive neurons. TRPA1 is activated by a variety of noxious stimuli, including cold temperatures, pungent compounds such as mustard oil and cinnamaldehyde, and intracellular alkalization. Here, we show that primary alcohols, which have been reported to cause skin, eye or nasal...

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Source

Identifiers

PMID: 22222967
DOI: 10.1007/s00424-011-1069-4

Genes

TRPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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