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Article

Genetic variants of microRNA-146a gene: an indicator of systemic lupus erythematosus susceptibility, lupus nephritis, and disease activity.

Molecular biology reports - 1 Oct 2020

Fouda Mona E, Nour El Din Dalia M, Mahgoub Marwa Y, Elashkar Amany E, Abdel Halim Walid A

Abstract excerpt

Genetic variations of microRNA encoding genes influence various sorts of diseases by modifying the expression or activity of microRNAs. MicroRNA 146a is an epigenetic regulator of immune response through controlling the type I interferon (IFN) and nuclear factor kappa B (NF-κB) pathways. Genetic variations of microRNA 146a impact the susceptibility to systemic lupus erythematosus (SLE) and its clinical...

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PMID: 32929657
DOI: 10.1007/s11033-020-05802-y

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