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Article

Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo.

RNA (New York, N.Y.) - 1 Sept 2008

Ramirez Alejandro, Shuman Stewart, Schwer Beate

Abstract excerpt

Yeast and human Clp1 proteins are homologous components of the mRNA 3'-cleavage-polyadenylation machinery. Recent studies highlighting an association of human Clp1 (hClp1) with tRNA splicing endonuclease and an intrinsic RNA-specific 5'-OH polynucleotide kinase activity of hClp1 have prompted speculation that Clp1 might play a catalytic role in tRNA splicing in animal cells. Here, we show that expression of hClp1...

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Identifiers

PMID: 18648070
DOI: 10.1261/rna.1142908
PMCID: PMC2525948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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