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Article

HNGF6A Inhibits Oxidative Stress-Induced MC3T3-E1 Cell Apoptosis and Osteoblast Phenotype Inhibition by Targeting Circ_0001843/miR-214 Pathway.

Calcified tissue international - 1 May 2020

Zhu Xiao, Zhao Ziping, Zeng Canjun, Chen Bo, Huang Haifeng, Chen Youming, Zhou Quan, Yang Li, Lv Jicheng, Zhang Jing, Pan Daoyan, Shen Jie, Duque Gustavo, Cai Daozhang

Abstract excerpt

Humanin (HN), a mitochondrial derived peptide, plays cyto-protective role under various stress. In this study, we aimed to investigate the effects of HNGF6A, an analogue of HN, on osteoblast apoptosis and differentiation and the underlying mechanisms. Cell proliferation of murine osteoblastic cell line MC3TC-E1 was examined by CCK8 assay and Edu staining. Cell apoptosis was detected by Annexin V assay under H2O2...

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PMID: 32189040
DOI: 10.1007/s00223-020-00660-z

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