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Article

On the pleiotropic structure of the genotype-phenotype map and the evolvability of complex organisms.

Genetics - 1 Mar 2012

Hill William G, Zhang Xu-Sheng

Abstract excerpt

Analyses of effects of mutants on many traits have enabled estimates to be obtained of the magnitude of pleiotropy, and in reviews of such data others have concluded that the degree of pleiotropy is highly restricted, with implications on the evolvability of complex organisms. We show that these conclusions are highly dependent on statistical assumptions, for example significance levels. We analyze models with...

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Identifiers

PMID: 22214609
DOI: 10.1534/genetics.111.135681
PMCID: PMC3296247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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