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Article

Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping.

PLoS biology - 1 Aug 2020

Geiler-Samerotte Kerry A, Li Shuang, Lazaris Charalampos, Taylor Austin, Ziv Naomi, Ramjeawan Chelsea, Paaby Annalise B, Siegal Mark L

Abstract excerpt

Pleiotropy-when a single mutation affects multiple traits-is a controversial topic with far-reaching implications. Pleiotropy plays a central role in debates about how complex traits evolve and whether biological systems are modular or are organized such that every gene has the potential to affect many traits. Pleiotropy is also critical to initiatives in evolutionary medicine that seek to trap infectious...

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Identifiers

PMID: 32804946
DOI: 10.1371/journal.pbio.3000836
PMCID: PMC7451985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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