Article
Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping.
PLoS biology - 1 Aug 2020
Geiler-Samerotte Kerry A, Li Shuang, Lazaris Charalampos, Taylor Austin, Ziv Naomi, Ramjeawan Chelsea, Paaby Annalise B, Siegal Mark L
Abstract excerpt
Pleiotropy-when a single mutation affects multiple traits-is a controversial topic with far-reaching implications. Pleiotropy plays a central role in debates about how complex traits evolve and whether biological systems are modular or are organized such that every gene has the potential to affec...
Topics
- Biological Evolution
- Cell Cycle
- Clone Cells
- Genetic Pleiotropy
- Genetic Variation
- High-Throughput Screening Assays
- Models, Genetic
- Multifactorial Inheritance
- Mutation
- Phenotype
- Quantitative Trait Loci
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Single-Cell Analysis