Article
Pleiotropic scaling of gene effects and the 'cost of complexity'.
Nature - 27 Mar 2008
Wagner Günter P, Kenney-Hunt Jane P, Pavlicev Mihaela, Peck Joel R, Waxman David, Cheverud James M
Abstract excerpt
As perceived by Darwin, evolutionary adaptation by the processes of mutation and selection is difficult to understand for complex features that are the product of numerous traits acting in concert, for example the eye or the apparatus of flight. Typically, mutations simultaneously affect multiple phenotypic characters. This phenomenon is known as pleiotropy. The impact of pleiotropy on evolution has for decades...
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