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PBHoover and CigarRoller: a method for confident haploid variant calling on Pacific Biosciences data and its application to heterogeneous population analysis

2018-07-02

Abstract excerpt

<h4>Motivation</h4> Single Molecule Real-Time (SMRT) sequencing has important and underutilized advantages that amplification-based platforms lack. Lack of systematic error (e.g. GC-bias), complete de novo assembly (including large repetitive regions) without scaffolding, can be mentioned. SMRT sequencing, however suffers from high random error rate and low sequencing depth (older chemistries). Here, we introduc...

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Literature Corpus work: b7a25909-706b-53e8-ad1f-d9ab7f619576
DOI: 10.1101/360370

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