Role of epigenetic and miR‐22 and miR‐29b alterations in the downregulation of <i>Mat1a</i> and <i>Mthfr</i> genes in early preneoplastic livers in rats induced by 2‐acetylaminofluorene

Abstract excerpt

Carcinogenesis is a multistep sequential process of clonal expansion of initiated cells associated with the accumulation of multiple cancer-specific heritable phenotypes. The acquisition of these heritable cancer-specific alterations may be triggered by mutational and/or non-mutational changes in the genome that affect the regulation of gene expression. Currently, cancer-specific epigenetically mediated changes...

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