Article
Systematic mutational analysis of the LytTR DNA binding domain of Staphylococcus aureus virulence gene transcription factor AgrA.
Nucleic acids research - 10 Nov 2014
Nicod Sophie S, Weinzierl Robert O J, Burchell Lynn, Escalera-Maurer Andres, James Ellen H, Wigneshweraraj Sivaramesh
Abstract excerpt
Most DNA-binding bacterial transcription factors contact DNA through a recognition α-helix in their DNA-binding domains. An emerging class of DNA-binding transcription factors, predominantly found in pathogenic bacteria interact with the DNA via a relatively novel type of DNA-binding domain, called the LytTR domain, which mainly comprises β strands. Even though the crystal structure of the LytTR domain of the...
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