Article
Non-V600E BRAF mutations and treatment for hairy cell leukemia.
Blood - 24 Apr 2025
Arons Evgeny, Tai Chin-Hsien, Suraj Joshi, Liu Yuelin, Day Chi-Ping, Raffeld Mark, Xi Liqiang, Zhou Hong, Gould Mory, Shpilman Isaac, Oakes Cristopher C, Bhat Seema, Grever Michael, Jones Daniel, Rogers Kerry, Wang Hao-Wei, Yuan Constance M, Sahinalp Cenk, Kreitman Robert J
Abstract excerpt
ABSTRACT: We found 20 patients with an immunophenotype consistent with classic hairy cell leukemia and BRAF mutations other than just V600E. Fourteen had 1 non-V600E BRAF mutation and 6 had V600E with 1 (n = 5) or 2 (n = 1) non-V600E BRAF comutations. This study was registered at https://clinicaltrials.gov as #NCT01087333.
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