Article
Synergistic roles for G-protein γ3 and γ7 subtypes in seizure susceptibility as revealed in double knock-out mice.
The Journal of biological chemistry - 2 Mar 2012
Schwindinger William F, Mirshahi Uyenlinh L, Baylor Kelly A, Sheridan Kathleen M, Stauffer Anna M, Usefof Stephanie, Stecker Mark M, Mirshahi Tooraj, Robishaw Janet D
Abstract excerpt
The functions of different G-protein αβγ subunit combinations are traditionally ascribed to their various α components. However, the discovery of similarly diverse γ subtypes raises the possibility that they may also contribute to specificity. To test this possibility, we used a gene targeting approach to determine whether the closely related γ(3) and γ(7) subunits can perform functionally interchangeable roles...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.