Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations.

doi:10.1002/gcc.21972

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Article

Different distribution of NOTCH1 mutations in chronic lymphocytic leukemia with isolated trisomy 12 or associated with other chromosomal alterations.

Genes, chromosomes & cancer - 1 Sept 2012

López Cristina, Delgado Julio, Costa Dolors, Conde Laura, Ghita Gabriela, Villamor Neus, Navarro Alba, Cazorla Maite, Gómez Cándida, Arias Amparo, Muñoz Concha, Baumann Tycho, Rozman María, Aymerich Marta, Colomer Dolors, Cobo Francesc, Campo Elías, López-Guillermo Armando, Montserrat Emili, Carrió Ana

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in Western countries. Chromosomal abnormalities commonly found using conventional cytogenetics and FISH are del(11)(q22-23), trisomy 12, del(13)(q14), and del(17)(p13). Trisomy 12 is the most frequent numerical abnormality in CLL. It can appear isolated or associated with other chromosomal aberrations, including t(14;18)(q32;q21) and...

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Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 12

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 22619094
DOI: 10.1002/gcc.21972

Genes

NOTCH1
BCL2
ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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