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Article

Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival.

Molecular cancer research : MCR - 1 Jun 2017

Ptashkin Ryan N, Pagan Carlos, Yaeger Rona, Middha Sumit, Shia Jinru, O'Rourke Kevin P, Berger Michael F, Wang Lu, Cimera Robert, Wang Jiajing, Klimstra David S, Saltz Leonard, Ladanyi Marc, Zehir Ahmet, Hechtman Jaclyn F

Abstract excerpt

Here, comprehensive analysis was performed on the molecular and clinical features of colorectal carcinoma harboring chromosome 20q amplification. Tumor and normal DNA from patients with advanced colorectal carcinoma underwent next-generation sequencing via MSK-IMPACT, and a subset of case samples was subjected to high-resolution microarray (Oncoscan). Relationships between genomic copy number and transcript...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28184012
DOI: 10.1158/1541-7786.MCR-16-0352
PMCID: PMC5588907

Genes

IMPACT
SRC
BRAF
KRAS

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