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Article

βPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin αvβ8.

Developmental biology - 1 Mar 2012

Liu Jing, Zeng Lei, Kennedy Regan M, Gruenig Nicole M, Childs Sarah J

Abstract excerpt

The growth of new blood vessels by angiogenesis and their stabilization by the recruitment of perivascular mural cells are thought to be two sequential, yet independent events. Here we identify molecular links between both processes through the βPix and integrin α(v)β(8) proteins. Bubblehead (bbh) mutants with a genetic mutation in βPix show defective vascular stabilization. βPix is a guanine nucleotide exchange...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22206757
DOI: 10.1016/j.ydbio.2011.12.022

Genes

GIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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