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CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells

1 May 2021

Abstract excerpt

Abstract Tetraspanins are often used as Extracellular Vesicle (EV) detection markers because of their abundance on these secreted vesicles. However, data on their function on EV biogenesis are controversial and compensatory mechanisms often occur upon gene deletion. To overcome this handicap, we have compared the effects of tetraspanin CD9 gene deletion with those elicited by cytopermeable peptides with blocking...

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PMID: 34012515
DOI: 10.1002/jev2.12082

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