Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna

1 Jan 2014

Abstract excerpt

Adeno-associated virus serotype 9 (AAV9) vectors have recently been shown to transduce cells throughout the central nervous system of nonhuman primates when injected into the cerebrospinal fluid (CSF), a finding which could lead to a minimally invasive approach to treat genetic and acquired diseases affecting the entire CNS. We characterized the transduction efficiency of two routes of vector administration into...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to RNA Interference and Gene Delivery
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26052519
DOI: 10.1038/mtm.2014.51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magnaPMID 26052519Read ↗

Pilot Study Assessing the Impact of Intrathecal Administration of Variants AAV-PHP.B and AAV-PHP.eB on Brain Transduction in Adult Rhesus MacaquesSemantic proximity Read ↗

Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman PrimatesSemantic proximity Read ↗

Comparison of AAV9-driven motor neuron transduction following different CNS-directed delivery methods in miceSemantic proximity Read ↗

Systemic Gene Delivery in Large Species for Targeting Spinal Cord, Brain, and Peripheral Tissues for Pediatric DisordersSemantic proximity Read ↗

Delivery of Adeno-Associated Virus Vectors to the Central Nervous System for Correction of Single Gene DisordersSemantic proximity Read ↗

Focused ultrasound increases gene delivery to deep brain structure following the administration of a recombinant adeno-associated virus in the cerebrospinal fluidSemantic proximity Read ↗

AAV serotype PHP.eB achieves superior neuronal transduction efficiency compared to AAV9 in pigtail macaques following intracerebroventricular administrationSemantic proximity Read ↗

Routes of administration for adeno-associated viruses carrying gene therapies for brain diseasesSemantic proximity Read ↗

The advent of AAV9 expands applications for brain and spinal cord gene deliverySemantic proximity Read ↗

Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice.Semantic proximity Read ↗

Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS VectorSemantic proximity Read ↗

Systemic delivery of scAAV9 in fetal macaques facilitates neuronal transduction of the central and peripheral nervous systemsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.