Article
Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer.
Anticancer research - 1 Dec 2011
Kobayashi Masashi, Sonobe Makoto, Takahashi Tsuyoshi, Yoshizawa Akihiko, Ishikawa Masashi, Kikuchi Ryutaro, Okubo Kenichi, Huang Cheng-Long, Date Hiroshi
Abstract excerpt
BACKGROUND: V-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations are attractive molecular targets for cancer treatment. Detection of BRAF gene mutation and analyses in non-small cell lung cancer (NSCLC) are of great scientific interest. PATIENTS AND METHODS: The study included 581 NSCLC patients (377 males, 204 female) undergoing pulmonary resection. BRAF gene mutations were screened using the PCR-SSCP...
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