Article
Functional genetic variants of c-Jun and their interaction with smoking and drinking increase the susceptibility to lung cancer in southern and eastern Chinese.
International journal of cancer - 1 Sept 2012
Huang Binfang, Liu Bin, Yang Lei, Li Yinyan, Cheng Mei, Huang Dongsheng, Wang Hui, Zhang Xin, Zheng Jian, Li Qingchu, Ji Weidong, Zhou Yifeng, Lu Jiachun
Abstract excerpt
Human proto-oncogene c-Jun and c-Fos assemble the activator protein-1 complex which is a crucial transcription factor responding to environmental factors and promotes tumorgenesis. We hypothesized that genetic variants in these two genes may alter the carriers' susceptibility to lung cancer. In two independent case-control studies, we genotyped three putative functional polymorphisms (-1318T>G and -673T>C of...
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