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Article

Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate.

Journal of translational medicine - 14 Nov 2011

Chiang Cheryl L-L, Maier Dawn A, Kandalaft Lana E, Brennan Andrea L, Lanitis Evripidis, Ye Qunrui, Levine Bruce L, Czerniecki Brian J, Powell Daniel J, Coukos George

Abstract excerpt

BACKGROUND: Dendritic cells (DCs) are the most potent antigen-presenting cell population for activating tumor-specific T cells. Due to the wide range of methods for generating DCs, there is no common protocol or defined set of criteria to validate the immunogenicity and function of DC vaccines. METHODS: Monocyte-derived DCs were generated during 4 days of culture with recombinant granulocyte-macrophage colony...

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Identifiers

PMID: 22082029
DOI: 10.1186/1479-5876-9-198
PMCID: PMC3283529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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