Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transient activation of hematopoietic stem and progenitor cells by IFNγ during acute bacterial infection.

PloS one - 1 Jan 2011

MacNamara Katherine C, Jones Maura, Martin Olga, Winslow Gary M

Abstract excerpt

How hematopoietic stem cells (HSCs) respond to inflammatory signals during infections is not well understood. Our studies have used a murine model of ehrlichiosis, an emerging tick-born disease, to address how infection impacts hematopoietic function. Infection of C57BL/6 mice with the intracellular bacterium, Ehrlichia muris, results in anemia and thrombocytopenia, similar to what is observed in human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Ataxin-1
Share to Ataxins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bacterial Infections

Share to Cell Separation

Share to Hematopoiesis

Share to Hematopoietic Stem Cells

Share to Proto-Oncogene Proteins c-kit

Source

Open in PubMed Open full text

Identifiers

PMID: 22194881
DOI: 10.1371/journal.pone.0028669
PMCID: PMC3237486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transient activation of hematopoietic stem and progenitor cells by IFNγ during acute bacterial infection.PMID 22194881Read ↗

Resolving Salmonella infection reveals dynamic and persisting changes in murine bone marrow progenitor cell phenotype and function.Semantic proximity Read ↗

Low Doses of Imatinib Induce Myelopoiesis and Enhance Host Anti-microbial ImmunitySemantic proximity Read ↗

Inflammation: a key regulator of hematopoietic stem cell fate in health and diseaseSemantic proximity Read ↗

The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and DiseaseSemantic proximity Read ↗

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal DifferentiationSemantic proximity Read ↗

The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice.Semantic proximity Read ↗

Infection-experienced HSPCs protect against infections by generating neutrophils with enhanced bactericidal activitySemantic proximity Read ↗

Single-cell analysis of CX3CR1 <sup>+</sup> cells reveal a pathogenic role for BIRC5 <sup>+</sup> myeloid proliferating cells driven by <i>Staphylococcus aureus</i> leukotoxinsSemantic proximity Read ↗

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal DifferentiationSemantic proximity Read ↗

Helminth infection favors reprogramming and proliferation of lung neutrophilsSemantic proximity Read ↗

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling.Semantic proximity Read ↗

cGAS-STING dependent type I IFN protects against <i>Leptospira interrogans</i> renal colonization in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.