Article
Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells.
PloS one - 1 Jan 2011
Cheung Phyllis Fung Yi, Cheng Christine Kei Chin, Wong Nicholas Chun Lim, Ho Jenny Chung Yee, Yip Chi Wai, Lui Vincent Chi Hang, Cheung Annie Nga Yin, Fan Sheung Tat, Cheung Siu Tim
Abstract excerpt
BACKGROUND AND AIMS: Increasing evidence has suggested that hepatocellular carcinoma (HCC) might originate from a distinct subpopulation called cancer stem cells (CSCs), which are responsible for the limited efficacy of conventional therapies. We have previously demonstrated that granulin-epithelin precursor (GEP), a pluripotent growth factor, is upregulated in HCC but not in the adjacent non-tumor, and that GEP...
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