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Article

KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.

Atherosclerosis - 1 Feb 2012

Akao Hironobu, Polisecki Eliana, Kajinami Kouji, Trompet Stella, Robertson Michele, Ford Ian, Jukema J Wouter, de Craen Anton J M, Westendorp Rudi G J, Shepherd James, Packard Christopher, Buckley Brendan M, Schaefer Ernst J

Abstract excerpt

Single nucleotide polymorphisms (SNPs) at the KIF6 (kinesin like protein 6, rs20455 or 719Arg), LPA (lipoprotein(a), rs3798220), TAS2R50 (taste receptor type 2, member 50, rs1376251) and VAMP8 (vesicle-associated membrane protein 8, rs1010) have previously been associated with low density lipopro...

Read the complete abstract on PubMed

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Topics

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Share to Cholesterol, LDL
Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors
Share to Hypercholesterolemia
Share to Kinesins
Share to Lipoprotein(a)
Share to Pravastatin
Share to R-SNARE Proteins
Share to Taste Receptors, Type 2

Source

Identifiers

PMID: 22192511
DOI: 10.1016/j.atherosclerosis.2011.11.037

Genes

KIF6
LPA
VAMP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22192511-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.PMID 22192511Read ↗

A Common KIF6 Polymorphism Increases Vulnerability to Low-Density Lipoprotein Cholesterol: Two Meta-Analyses and a Meta-Regression AnalysisSemantic proximity Read ↗

Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention.Semantic proximity Read ↗

Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial.Semantic proximity Read ↗

Impact of the 719Arg Variant of KIF6 and Major Cardiovascular Events on Patients who Received Statins: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

<i>KIF6</i> Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER studySemantic proximity Read ↗

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: the 4D study.Semantic proximity Read ↗

Genetic variants in the KIF6 region and coronary event reduction from statin therapy.Semantic proximity Read ↗

Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians.Semantic proximity Read ↗

No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.Semantic proximity Read ↗

The 719Arg variant of KIF6 and cardiovascular outcomes in statin-treated, stable coronary patients of the treating to new targets and incremental decrease in end points through aggressive lipid-lowering prospective studies.Semantic proximity Read ↗

Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.Semantic proximity Read ↗

Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.Semantic proximity Read ↗

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