Genetic variants in the KIF6 region and coronary event reduction from statin therapy.

doi:10.1007/s00439-010-0892-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic variants in the KIF6 region and coronary event reduction from statin therapy.

Human genetics - 1 Jan 2011

Li Yonghong, Sabatine Marc S, Tong Carmen H, Ford Ian, Kirchgessner Todd G, Packard Christopher J, Robertson Michele, Rowland Charles M, Bare Lance A, Shepherd James, Devlin James J, Iakoubova Olga A

Abstract excerpt

A single nucleotide polymorphism (SNP) in KIF6, a member of the KIF9 family of kinesins, is associated with differential coronary event reduction from statin therapy in four randomized controlled trials; this SNP (rs20455) is also associated with the risk for coronary heart disease (CHD) in multiple prospective studies. We investigated whether other common SNPs in the KIF6 region were associated with event...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronary Disease

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Kinesins

Share to Linkage Disequilibrium

Share to Meta-Analysis as Topic

Share to Polymorphism, Single Nucleotide

Share to Randomized Controlled Trials as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 20886236
DOI: 10.1007/s00439-010-0892-6
PMCID: PMC3016221

Genes

KIF6
KIF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants in the KIF6 region and coronary event reduction from statin therapy.PMID 20886236Read ↗

Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.Semantic proximity Read ↗

Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial.Semantic proximity Read ↗

Impact of the 719Arg Variant of KIF6 and Major Cardiovascular Events on Patients who Received Statins: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect.Semantic proximity Read ↗

The 719Arg variant of KIF6 and cardiovascular outcomes in statin-treated, stable coronary patients of the treating to new targets and incremental decrease in end points through aggressive lipid-lowering prospective studies.Semantic proximity Read ↗

Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.Semantic proximity Read ↗

A Common KIF6 Polymorphism Increases Vulnerability to Low-Density Lipoprotein Cholesterol: Two Meta-Analyses and a Meta-Regression AnalysisSemantic proximity Read ↗

<i>KIF6</i> Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER studySemantic proximity Read ↗

The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis.Semantic proximity Read ↗

Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians.Semantic proximity Read ↗

No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.Semantic proximity Read ↗

Association between KIF6 rs20455 polymorphism and the risk of coronary heart disease (CHD): a pooled analysis of 50 individual studies including 40,059 cases and 64,032 controls.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.