Article
The 719Arg variant of KIF6 and cardiovascular outcomes in statin-treated, stable coronary patients of the treating to new targets and incremental decrease in end points through aggressive lipid-lowering prospective studies.
Circulation. Cardiovascular genetics - 1 Feb 2012
Arsenault Benoit J, Boekholdt S Matthijs, Hovingh G Kees, Hyde Craig L, DeMicco David A, Chatterjee Aurobindo, Barter Philip, Deedwania Prakash, Waters David D, LaRosa John C, Pedersen Terje R, Kastelein John J P
Abstract excerpt
BACKGROUND: Carriers of the KIF6 719Arg variant may be at increased risk for CVD and may benefit more from statin therapy, in terms of CVD risk reduction, than noncarriers. Our objective was to investigate whether carriers of the KIF6 719Arg genetic variant (rs20455) are at increased cardiovascular risk and obtain more benefit from high-dose statin therapy than do noncarriers. METHODS AND RESULTS: We used an...
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