Article
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and cardiovascular risk and efficacy of atorvastatin among subjects with diabetes on dialysis: the 4D study.
Atherosclerosis - 1 Dec 2011
Hoffmann Michael M, März Winfried, Genser Bernd, Drechsler Christiane, Wanner Christoph
Abstract excerpt
AIMS: We investigated whether KIF6 Trp719Arg genotypes affect cardiovascular outcomes and efficacy of statin therapy in patients with type 2 diabetes mellitus undergoing hemodialysis. METHODS AND RESULTS: We conducted a post hoc analysis of the 4D-study, a randomized trial including 1255 patients. Patients were randomly assigned to double-blind treatment with either 20mg of atorvastatin (n = 619) or placebo (n =...
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