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Oxazolidinones: mechanisms of resistance and mobile genetic elements involved

21 Aug 2022

Abstract excerpt

The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind to the peptidyl transferase centre of the bacterial ribosome inhibiting protein synthesis. Even if the majority of Gram-positive bacteria remain susceptible to oxazolidinones, resistant isolates have been reported worldwide. Apart...

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PMID: 35989417
DOI: 10.1093/jac/dkac263

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