Article
Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis.
Genes and immunity - 1 Apr 2012
Lin C P, Adrianto I, Lessard C J, Kelly J A, Kaufman K M, Guthridge J M, Freedman B I, Anaya J-M, Alarcón-Riquelme M E, Pons-Estel B A, Martin J, Glenn S, Adler A, Bae S-C, Park S-Y, Bang S-Y, Song Y-W, Boackle S A, Brown E E, Edberg J C, Alarcón G S, Petri M A, Criswell L A, Ramsey-Goldman R, Reveille J D, Vila L M, Gilkeson G S, Kamen D L, Ziegler J, Jacob C O, Rasmussen A, James J A, Kimberly R P, Merrill J T, Niewold T B, Scofield R H, Stevens A M, Tsao B P, Vyse T J, Langefeld C D, Moser K L, Harley J B, Gaffney P M, Montgomery C G
Abstract excerpt
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production and organ damage. Lupus nephritis (LN) is one of the most severe manifestations of SLE. Multiple studies reported associations between renal diseases and variants in the non-muscle myosin heavy chain 9 (MYH9) and the neighboring apolipoprotein L 1 (APOL1) genes. We evaluated 167 variants spanning MYH9 for...
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