Article
APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy.
Journal of the American Society of Nephrology : JASN - 1 Nov 2011
Papeta Natalia, Kiryluk Krzysztof, Patel Ami, Sterken Roel, Kacak Nilgun, Snyder Holly J, Imus Phil H, Mhatre Anand N, Lawani Anil K, Julian Bruce A, Wyatt Robert J, Novak Jan, Wyatt Christina M, Ross Michael J, Winston Jonathan A, Klotman Mary E, Cohen David J, Appel Gerald B, D'Agati Vivette D, Klotman Paul E, Gharavi Ali G
Abstract excerpt
A chromosome 22q13 locus strongly associates with increased risk for idiopathic focal segmental glomerulosclerosis (FSGS), HIV-1-associated nephropathy (HIVAN), and hypertensive ESRD among individuals of African descent. Although initial studies implicated MYH9, more recent analyses localized the strongest association within the neighboring APOL1 gene. In this replication study, we examined the six top-most...
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