Article
BRCA1 is an essential regulator of heart function and survival following myocardial infarction.
Nature communications - 20 Dec 2011
Shukla Praphulla C, Singh Krishna K, Quan Adrian, Al-Omran Mohammed, Teoh Hwee, Lovren Fina, Cao Liu, Rovira Ilsa I, Pan Yi, Brezden-Masley Christine, Yanagawa Bobby, Gupta Aanika, Deng Chu-Xia, Coles John G, Leong-Poi Howard, Stanford William L, Parker Thomas G, Schneider Michael D, Finkel Toren, Verma Subodh
Abstract excerpt
The tumour suppressor BRCA1 is mutated in familial breast and ovarian cancer but its role in protecting other tissues from DNA damage has not been explored. Here we show a new role for BRCA1 as a gatekeeper of cardiac function and survival. In mice, loss of BRCA1 in cardiomyocytes results in adverse cardiac remodelling, poor ventricular function and higher mortality in response to ischaemic or genotoxic stress....
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