Article
Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females.
Respiratory research - 20 Dec 2011
Dempsie Yvonne, Nilsen Margaret, White Kevin, Mair Kirsty M, Loughlin Lynn, Ambartsumian Noona, Rabinovitch Marlene, Maclean Margaret R
Abstract excerpt
BACKGROUND: Idiopathic and familial forms of pulmonary arterial hypertension (PAH) occur more frequently in women than men. However, the reason for this remains unknown. Both the calcium binding protein S100A4/Mts1 (Mts1) and its endogenous receptor (receptor for advanced glycosylation end products; RAGE) have been implicated in the development of PAH. We wished to investigate if the Mts1/RAGE pathway may play a...
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