Article
Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2012
Salvi Erika, Kutalik Zoltán, Glorioso Nicola, Benaglio Paola, Frau Francesca, Kuznetsova Tatiana, Arima Hisatomi, Hoggart Clive, Tichet Jean, Nikitin Yury P, Conti Costanza, Seidlerova Jitka, Tikhonoff Valérie, Stolarz-Skrzypek Katarzyna, Johnson Toby, Devos Nabila, Zagato Laura, Guarrera Simonetta, Zaninello Roberta, Calabria Andrea, Stancanelli Benedetta, Troffa Chiara, Thijs Lutgarde, Rizzi Federica, Simonova Galina, Lupoli Sara, Argiolas Giuseppe, Braga Daniele, D'Alessio Maria C, Ortu Maria F, Ricceri Fulvio, Mercurio Maurizio, Descombes Patrick, Marconi Maurizio, Chalmers John, Harrap Stephen, Filipovsky Jan, Bochud Murielle, Iacoviello Licia, Ellis Justine, Stanton Alice V, Laan Maris, Padmanabhan Sandosh, Dominiczak Anna F, Samani Nilesh J, Melander Olle, Jeunemaitre Xavier, Manunta Paolo, Shabo Amnon, Vineis Paolo, Cappuccio Francesco P, Caulfield Mark J, Matullo Giuseppe, Rivolta Carlo, Munroe Patricia B, Barlassina Cristina, Staessen Jan A, Beckmann Jacques S, Cusi Daniele
Abstract excerpt
Essential hypertension is a multifactorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases and controls...
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