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Article

Alendronate Affects Osteoblast Functions by Crosstalk through EphrinB1-EphB

15 Dec 2011

Abstract excerpt

Bisphosphonates are therapeutic agents in the treatment of post-menopausal osteoporosis. Although they have been associated with delayed healing in injured tissues, inappropriate femoral fractures, and osteonecrosis of the jaw (ONJ), the pathophysiological mechanisms involved are not clear. Our hypothesis is that alendronate, a member of the N-containing bisphosphonates, indirectly inhibits osteoblast function...

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PMID: 22180568
DOI: 10.1177/0022034511432170

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