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Article

Critical catalytic functional groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.

Acta crystallographica. Section D, Biological crystallography - 1 Oct 2004

Blanco Julio, Moore Roger A, Faehnle Christopher R, Viola Ronald E

Abstract excerpt

Aspartate-beta-semialdehyde dehydrogenase (ASADH) catalyzes the reductive dephosphorylation of beta-aspartyl phosphate to L-aspartate-beta-semialdehyde in the aspartate biosynthetic pathway. This pathway is not found in humans or other eukaryotic organisms, yet is required for the production of threonine, isoleucine, methionine and lysine in most microorganisms. The mechanism of this enzyme has been examined...

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PMID: 15388927
DOI: 10.1107/S0907444904020104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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