Article
Temperature dependence of the aggregation kinetics of Sup35 and Ure2p yeast prions.
Biomacromolecules - 13 Feb 2012
Sabaté Raimon, Villar-Piqué Anna, Espargaró Alba, Ventura Salvador
Abstract excerpt
Fungal prions are protein-based genetic elements. Sup35 and Ure2p constitute the best-characterized prion proteins in the yeast Saccharomyces cerevisiae. No high-resolution molecular models of the amyloid conformations adopted by the prion domains of these proteins are available yet. A quantitative description of the kinetics and thermodynamics of their self-assembly processes might provide clues on the nature of...
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