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Article

Stretch-induced hypertrophy activates NFkB-mediated VEGF secretion in adult cardiomyocytes.

PloS one - 1 Jan 2011

Leychenko Anna, Konorev Eugene, Jijiwa Mayumi, Matter Michelle L

Abstract excerpt

Hypertension and myocardial infarction are associated with the onset of hypertrophy. Hypertrophy is a compensatory response mechanism to increases in mechanical load due to pressure or volume overload. It is characterized by extracellular matrix remodeling and hypertrophic growth of adult cardiomyocytes. Production of Vascular Endothelial Growth Factor (VEGF), which acts as an angiogenic factor and a modulator of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22174951
DOI: 10.1371/journal.pone.0029055
PMCID: PMC3236775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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