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Article

Mechanical strain activates BNP gene transcription through a p38/NF-kappaB-dependent mechanism.

The Journal of clinical investigation - 1 Dec 1999

Liang F, Gardner D G

Abstract excerpt

Application of mechanical strain to neonatal rat ventricular myocytes in culture evokes changes in gene expression reminiscent of those that occur with hypertrophy in vivo, such as stimulation of brain natriuretic peptide (BNP) gene expression. Here, we show that a major component of strain-dependent BNP promoter activation results from stimulation of p38 mitogen-activated protein kinase (MAPK) in the cardiac...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Natriuretic Peptide, Brain

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Source

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Identifiers

PMID: 10587524
DOI: 10.1172/JCI7362
PMCID: PMC409860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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