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Article

Genetic background influences mitochondrial function: modeling mitochondrial disease for therapeutic development.

Trends in molecular medicine - 1 May 2010

Bénit Paule, El-Khoury Riyad, Schiff Manuel, Sainsard-Chanet Annie, Rustin Pierre

Abstract excerpt

Genetic background strongly influences the phenotype of human mitochondrial diseases. Mitochondrial biogenesis and function require up to 1500 nuclear genes, providing myriad opportunities for effects on disease expression. Phenotypic variability, combined with relative rarity, constitutes a major obstacle to establish cohorts for clinical trials. Animal models are, therefore, potentially valuable. However,...

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PMID: 20382561
DOI: 10.1016/j.molmed.2010.03.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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