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Article

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction.

Journal of the American Chemical Society - 25 Jan 2012

Stojković Vanja, Perissinotti Laura L, Willmer Daniel, Benkovic Stephen J, Kohen Amnon

Abstract excerpt

A significant contemporary question in enzymology involves the role of protein dynamics and hydrogen tunneling in enhancing enzyme catalyzed reactions. Here, we report a correlation between the donor-acceptor distance (DAD) distribution and intrinsic kinetic isotope effects (KIEs) for the dihydrofolate reductase (DHFR) catalyzed reaction. This study compares the nature of the hydride-transfer step for a series of...

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Identifiers

PMID: 22171795
DOI: 10.1021/ja209425w
PMCID: PMC4341912

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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