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Article

Effects of a distal mutation on active site chemistry.

Biochemistry - 7 Feb 2006

Wang Lin, Tharp Scott, Selzer Tzvia, Benkovic Stephen J, Kohen Amnon

Abstract excerpt

Previous studies of Escherichia coli dihydrofolate reductase (ecDHFR) have demonstrated that residue G121, which is 19 A from the catalytic center, is involved in catalysis, and long distance dynamical motions were implied. Specifically, the ecDHFR mutant G121V has been extensively studied by various experimental and theoretical tools, and the mutation's effect on kinetic, structural, and dynamical features of...

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PMID: 16445280
DOI: 10.1021/bi0518242
PMCID: PMC2553318

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